France has documented the first human death attributed to the Shamonda virus, an agent previously associated exclusively with animal infections. The patient, who suffered from severe immune deficiency, passed away in early October after developing brain complications linked to the virus. Part of the orthobunyavirus family, the virus is spread by biting midges and primarily affects livestock, such as cattle, sheep, and goats. First discovered in Nigeria in the 1960s, the virus has recently spread across Europe, including detections in Germany, Switzerland, and Austria. Scientific knowledge regarding human symptoms and transmission remains limited, and there is currently no vaccine to prevent the infection.